It uses thousands of vaccine coated pins that perforate into the skin. While this may seem like a miracle for anyone with a fear of needles, it may do more for poorer countries. Nov 19, 2014 the nextgeneration vaccine delivery system, created by vaxxas, is called the nanopatch and is the size of an adult thumbnail. Jan 11, 20 so far, kendall s research team at the university of queenslands institute for biotechnology and nanotechnology have tested the nanopatch on mice using various inoculations including against flu, the human papillomavirus hpv that causes cervical cancer, and even with a potential new vaccine against mosquitoborne viral disease chikungunya. Highdensity microprojection array delivery to rat skin of low doses. Nanopatchrevolutionising treatment of disease across the. After 160 years, its time to throw away the needle and. Kendall is an inventor on several nanopatch patents. Arc future fellow pioneers needlefree immunisation for the. Feb 25, 20 uq startup vaxxas is developing needlefree vaccination technology based on the research of professor mark kendall at the australian institute for bioengineering and nanotechnology.
Nanopatch technology developed by professor mark kendall could have a global impact by improving vaccines so they no longer have to be. So far, kendalls research team at the university of queenslands institute for biotechnology and nanotechnology have tested the nanopatch on mice using various inoculations including against flu, the human papillomavirus hpv that causes cervical cancer, and even with a potential new vaccine against mosquitoborne viral disease chikungunya. Mark kendall has a new medical invention that will make anyone with a fear of needles very happy. The nanopatch kendalls work drew the attention of the cdc and the world health organization. Nov 09, 2016 mark kendall and his colleagues have shown they are able to coat nanopatch microprojections with a vaccine, apply the nanopatch to the skin and achieve vaccination with one tenth to one thirtieth. Biomedical engineer mark kendall is revolutionizing the way lifesaving vaccines are delivered. Professor mark kendall is the creator of nanopatch and founder of the company vaxxas. Professor mark kendall is planning to dispatch the 160yearold needle and syringe to history.
Nanopatch polio vaccine success uq news the university of. Safety, tolerability, acceptability and immunogenicity of. An advanced platform that vaccinates by applying a patch to the skin for a few seconds. Jun 12, 20 mark kendall has a new medical invention that will make anyone with a fear of needles very happy. Vaccine technology is improving, mark says, but many times you dont know if a vaccine will work until you roll up your sleeves and put the vaccine into a body. Looking a bit like a fuzzy computer chip, the nanopatch uses tiny powdercoated spikes to deliver a small dose of vaccine just under the skin, immunizing a person in about a minute. Smaller than a postage stamp and covered in vaccinecoated microscopic projections, the nanopatch promises to save lives.
Needlefree vaccination and vaccine delivery solutions that safely and cost effectively amplify vaccine efficacy using nanopatch technology developed by. He used his background in aerodynamics to create a gene gun. One hundred sixty years after the invention of the needle and syringe, were still using them to deliver vaccines. Jan 14, 20 a biomedical engineer has developed a tiny patch that could replace the need for needledelivered vaccines. He is an entrepreneurial professor of the australian national university.
Dry, needlefree vaccines exist and are saving lives. Needlefree vaccine delivery i am the inventor of the nanopatch. The money will enable university of queenslands professor. Dry, needlefree vaccines exist and are saving lives explorer moments. May 23, 2019 mark kendall has a new medical invention that will make anyone with a fear of needles very happy. Vaxxas nanopatch vaccine delivery system wearable technologies. Professor mark kendall, an inaugural arc future fellow at the university of. Professor kendall heads a team responsible for the development of the nanopatch, a breakthrough technology that is a. Mark kendall and the nanopatch technology 547 words. Upon nanopatch application, silicon microprojections coated with vaccine deliver their payload directly into the vicinity of a network of skin antigenpresenting cells. Kendalls laboratory at the university of queensland, and dr.
The nanopatch has two major advantages over traditional vaccination methods. Jan 09, 2019 vaxxas, a brisbane, australiabased company, develops and commercializes needlefree vaccine delivery system. Mark kendall and the nanopatch technology 547 words bartleby. In 2015, kendalls team, in collaboration with the world health organization who and the us centres for disease control and prevention, tested an inactivated poliovirus vaccine on rats using the nanopatch. Kendalls 10 research works with 11 citations and 452 reads, including.
Professor kendall heads a team responsible for the development of the nanopatch, a breakthrough technology that is a bit like a postage stamp that sticks on the skin. Nanopatch polio vaccine delivers uq news the university. Delivery of a polio vaccine with the nanopatch was demonstrated by uqs professor mark kendall and his research team at uqs australian institute for bioengineering and nanotechnology, in. Mark kendall and his colleagues have shown they are able to coat nanopatch microprojections with a vaccine, apply the nanopatch to the skin.
Arc future fellow pioneers needlefree immunisation for. Jan 14, 2014 biomedical engineer mark kendall demos the nanopatch, a onecentimeterbyonecentimeter square vaccine that can be applied painlessly to the skin. Nanopatch microprojections breach the stratum corneum and penetrate into the viable epidermis and dermis. So, what did the professor at the university of queensland invent. Drycoated live viral vector vaccines delivered by nanopatch. Vaccine technology earns honour for australian mark kendall. Nanopatch is the vaccine delivery system for people who. Apr 25, 2017 the nanopatch has two major advantages over traditional vaccination methods. Aug 30, 2012 just below the skin is an abundant supply of immune cells so the amount of vaccine required is a hundred fold less.
Mark kendall earned the young florey medal in 2016 for developing a breakthrough in vaccines. University of queensland efforts to rid the world of polio have taken another. Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell. His field of research is the delivery of immunotherapeutics to the skin without the use of a needle or syringe. Vaccine patch nanopinpoints flu inoculation popular science. Bioengineer developing needlefree nanopatch vaccines. The nanopatch delivers vaccines without needles a moonshot. Kendall, delivery of drugs and genes group, d2g2, the australian institute for bioengineering and nanotechnology aibn, the university of queensland, brisbane, qld, australia november 17th, 2016 at 4. Animal testing showed that nanopatch delivery outperforms needle delivery. Nov 14, 2016 biomedical engineer mark kendall s needlefree nanopatch is tinier than a postage stamp but huge on potential impact. Engineered to directly deposit vaccine amongst dense population of key immune cells in the skin, developing an efficient and effective immune response. The nanopatch was designed with these desirables in mind, with the aim of circumventing current logistical challenges presented by needle delivery of liquid vaccine. Nanopatch creator mark kendall science meets business. He shows how this tiny piece of silicon can overcome four major shortcomings of the modern needle and syringe.
Developed by university queensland bioengineer professor mark kendall, the nanopatch is a one centimetre square of silicone, studded with 20,000 vaccine coated micro projections that perforate the. The nanopatch is just as effective as needlebased mechanisms, said. The nanopatch contains an ultrahigh density array 0cm2 of short. Bioengineer developing needlefree nanopatch vaccines reuters. Vaxxas, a brisbane, australiabased company, develops and commercializes needlefree vaccine delivery system. A biomedical engineer has developed a tiny patch that could replace the need for needledelivered vaccines. Needleless vaccines one step closer with nanopatch. Based on looks alone, the nanopatch lives up to its name. Here we report a randomised, partlyblinded, placebocontrolled trial that represents the first use in humans of the np to deliver a vaccine.
Mark kendall and the nanopatch technology 547 words 2 pages a needlefree vaccine patch thats safer and way cheaper today, vaccination is regarded to as one of the greatest medical achievements. Hes invented a new vaccine technology thats painless, uses a fraction of the dose, puts the vaccine just under the skin, and doesnt require a fridge. Vaxxas is a company working to improve current vaccines and create the next generation of immunizations. View mark kendalls profile on linkedin, the worlds largest professional community. Professor mark kendall, an inaugural arc future fellow at the university of queensland, is a pioneer in needlefree immunisation technology that promises to eliminate the need for needles and syringes for vaccine delivery. Kendall was one of the founders of vaxxas and served as the chief technology officer at vaxxas and as professor at the university of queensland during the course of most of the. Nanopatch is a small square of silicon that sticks on the skin like a postage stamp and delivers vaccine directly to the bodys immune system.
A new malaria vaccine begins testing in malawi and more. See the complete profile on linkedin and discover marks connections and jobs at similar companies. Nanopatch polio vaccine success uq news the university. According to vaxxas, not only is it needlefree, but this technology can save on money and promise greater safety. Patch inventor professor mark kendall said the study exhibited a key advantage of the nanopatch. A new malaria vaccine begins testing in malawi and more ted.
A vaccine is a biological preparation that provides active acquired immunity to a particular disease. Oct 05, 2017 patch inventor professor mark kendall said the study exhibited a key advantage of the nanopatch. The nextgeneration vaccine delivery system, created by vaxxas, is called the nanopatch and is the size of an adult thumbnail. His field of research is the delivery of immunotherapeutics to the skin without the use of a needle or syringe biography. Needle free vaccinations coming to australia via the nanopatch. Professor kendall said the nanopatch has been tested for every class of vaccine including influenza, malaria and cervical cancer.
The nanopatch, invented by university of queensland biomedical engineer mark kendall, is a postage stampsized silicon wafer with thousands of microscopic projections with tips drycoated in vaccine. Its portability could help lower global mortality rates from tuberculosis. Kendall hopes to produce vaccines that cost 50 cents per dose. Aug 02, 2011 needleless vaccines one step closer with nanopatch. Uq startup vaxxas is developing needlefree vaccination technology based on the research of professor mark kendall at the australian institute. Mark kendall aims to shake up how vaccines are delivered with the nanopatch. The nanopatch has the potential to improve global health.
A vaccine typically contains an agent that resembles a diseasecausing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. Australian nanopatch may replace current polio vaccine. He graduated from university of queensland, where he began his engineering studies in 1990. His team has partnered with the world health organisation to run a. Uq technology with the power to revolutionise global vaccine delivery. His idea was to fire a vaccine directly into the skin. Nanopatch polio vaccine delivers 5 october 2017 nanopatch inventor professor mark kendall. Mark kendalls nanopatch could revolutionize infectious disease protection for. Arc future fellow pioneers needlefree immunisation for the world. It targets the abundant immune cell populations in the skins outer layers, rather than muscle, resulting in a more efficient vaccine delivery system, professor kendall said.
Prof mark kendall the nanopatch presents the possibility of just using a. Mark kendall wins csl young florey medal with nanopatch. Because the nanopatch is costeffective, it would be easier to access in impoverished areas. Biomedical engineer mark kendalls needlefree nanopatch is tinier than a postage stamp but huge on potential impact. This may sound scary however it is highly effective. If less vaccine is needed per person, more individuals can be vaccinated. When it comes to protecting millions of people from deadly infectious diseases, mark kendall thinks a fingertipsized patch covered in thousands of vaccinecoated microscopic spikes is. The nanopatch np is a microarray skin patch comprised of a highdensity array of microprojections drycoated with vaccine that is being developed to address these shortcomings. Professor mark kendall, an inaugural arc future fellow who has also received support from the arc discovery projects scheme, developed nanopatch. The company is working on boosting the performance of existing vaccines through a novel vaccine delivery technology called nanopatch.
Mark kendall born 1972 is an australian biomedical engineer and innovator. Biomedical engineer mark kendall demos the nanopatch, a onecentimeterbyonecentimeter square vaccine that can be applied painlessly to the skin. He shows how this tiny piece of silicon can overcome four major shortcomings of the modern needle and syringe, at a fraction of the cost. Just below the skin is an abundant supply of immune cells so the amount of vaccine required is a hundred fold less. Delivery of a polio vaccine with the nanopatch was demonstrated by uqs professor mark kendall and his research team at uqs australian institute for bioengineering and nanotechnology, in collaboration with the world health organisation, the us centres for disease control and prevention, and vaccine technology company vaxxas. The nanopatch works similarly to a nicotine patch, administering vaccine for skin absorption directly. Immune response and reactogenicity of an unadjuvanted. Nanopatch is the vaccine delivery system for people who fear. Each nanopatch consists of a 16 mm 2 silicon base with 3364 microprojections 21, 025 cm. Biomedical engineer mark kendalls innovative nanopatch could revolutionize medical vaccinations.